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Chemical Description

EDTA is a chelating agent used to sequester metal ions.

Medical Use and Chelating Properties

Edetic Acid (EDTA) is utilized as a medication for managing and treating heavy metal toxicity. It belongs to the chelating class of drugs and is effective in binding heavy metals, aiding in their removal from the body.

Application in Psoriasis Treatment

EDTA has been studied for over 60 years in the context of psoriasis treatment. As a metal-chelating agent, it has shown promise in managing symptoms and understanding the condition better. It helps in reducing non-specific serum protein interactions in enzyme immunoassays and is utilized in immunoanalysis to detect specific cells, such as CD3 cells.

Enzyme Analysis and Genetic Studies

EDTA plays a crucial role in analyzing enzymes involved in biochemical pathways related to psoriasis. It stabilizes enzymes extracted from psoriatic lesions, allowing for detailed enzymatic analysis. Additionally, EDTA blood samples have been used for genotyping studies to understand genetic correlations in psoriatic patients.

Antioxidant Properties

Some researchers have explored the antioxidant properties of EDTA in combating psoriasis. This aspect adds to the multifaceted approach in utilizing EDTA for psoriasis management.

Controversy in Regenerative Endodontic Procedures (REPs)

The effects of EDTA on regenerative endodontic procedures are controversial. While EDTA aids in releasing growth factors from dentine, some studies show negative effects on cell behavior. However, the complementary use of EDTA may help reduce endotoxins in contaminated root canals and promote the exposure of bioactive molecules essential for pulp-dentine complex regeneration.