453-20-3
- Product Name：3-Hydroxy-THF
- Molecular Formula：C4H8O2
- Purity：99%
- Molecular Weight：88.1063
Product Details;
CasNo： 453-20-3
Molecular Formula： C4H8O2
Appearance： light yellow liquid
Factory Sells Best Quality 3-Hydroxy-THF 453-20-3 with stock
- Molecular Formula:C4H8O2
- Molecular Weight:88.1063
- Appearance/Colour:light yellow liquid
- Vapor Pressure:760 mm Hg ( 181 °C)
- Melting Point:25°C
- Refractive Index:n20/D 1.45(lit.)
- Boiling Point:181 °C at 760 mmHg
- PKA:14.49±0.20(Predicted)
- Flash Point:81.1 °C
- PSA：29.46000
- Density:1.148 g/cm3
- LogP:-0.23240
3-Hydroxytetrahydrofuran(Cas 453-20-3) Usage
3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid compound with the molecular formula C4H8O2. It's a useful pharmaceutical intermediate, particularly the enantiopure (S) version, which is used in the synthesis of retroviral drugs. It's also used in the synthesis of other drugs like antiarrhythmic, hypoglycemic, and anticancer agents.
InChI:InChI=1/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2
453-20-3 Relevant articles
Preparation method of hydroxytetrahydrofuran compound
-
Paragraph 0044-0069, (2021/08/19)
The invention discloses a preparation me...
Preparation method of hydroxyl oxacycloalkane derivative
-
Paragraph 0049-0070, (2021/08/14)
The invention relates to a preparation m...
Preparation of Highly Active Monometallic Rhenium Catalysts for Selective Synthesis of 1,4-Butanediol from 1,4-Anhydroerythritol
Wang, Tianmiao,Tamura, Masazumi,Nakagawa, Yoshinao,Tomishige, Keiichi
, p. 3615 - 3626 (2019/07/15)
1,4-Butanediol can be produced from 1,4-...
One-pot catalytic selective synthesis of 1,4-butanediol from 1,4-anhydroerythritol and hydrogen
Wang, Tianmiao,Liu, Sibao,Tamura, Masazumi,Nakagawa, Yoshinao,Hiyoshi, Norihito,Tomishige, Keiichi
supporting information, p. 2547 - 2557 (2018/06/18)
A physical mixture of ReOx-Au/CeO2 and c...
453-20-3 Process route
-
- 1191-99-7,75454-45-4
2,3-dihydro-2H-furan
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- 5371-52-8
2-hydroxytetrahydrofuran
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- 453-20-3,84921-89-1,864447-89-2
3-Hydroxytetrahydrofuran
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- 71780-57-9
tetrahydrofuran-2'-yl ether
| Conditions | Yield |
|---|---|
|
With water; hydrogen; In 1,4-dioxane; at 139.84 ℃; for 4h; under 60006 Torr;
|
46% 18% 8% |
|
With water; hydrogen; pyrographite; In 1,4-dioxane; at 139.84 ℃; for 4h; under 60006 Torr;
|
46% 18% 8% |
-
- 3068-00-6,6810-31-7
D,L-1,2,4-butanetriol
-
- 109-99-9,24979-97-3,77392-70-2
tetrahydrofuran
-
- 453-20-3,84921-89-1,864447-89-2
3-Hydroxytetrahydrofuran
-
- 71-23-8
propan-1-ol
-
- 57-55-6,63625-56-9
propylene glycol
-
- 110-63-4
Butane-1,4-diol
-
- 18826-95-4,107-88-0
1.3-butanediol
-
- 56-81-5,25618-55-7,64333-26-2,8013-25-0
glycerol
-
- 4358-64-9
cis-1,4-anhydroerythritol
-
- 513-85-9
2.3-butanediol
-
- 584-03-2
1,2-dihydroxybutane
| Conditions | Yield |
|---|---|
|
With hydrogen; In water; at 200 ℃; for 31h; under 60006 Torr; Pressure; Reagent/catalyst; Autoclave;
|
453-20-3 Upstream products
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285-69-8
3,4-epoxytetrahydrofuran
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22929-52-8
tetrahydrofuran-3-one
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homoalylic alcohol
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7124-17-6
4-ethoxy-1,2-dibromo-butane
453-20-3 Downstream products
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2419-74-1
1,4-dichlorobutan-2-ol
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19398-47-1
1,4-dibromo-2-butanol
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131076-15-8
3-Benzoyloxytetrahydrofuran
-
13694-84-3
tetrahydro-3-furanyl tosylate
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