What is the 2,3,5,6-Tetrafluoropyridine?

2,3,5,6-Tetrafluoropyridine is clear colorless liquid, while it's Molecular Formula is C5HF4N. clear colorless liquid Used in Pharmaceutical Industry: 2,3,5,6-Tetrafluoropyridine is used as an intermediate for the development of various medicines. Its strong electronegativity and unique chemical properties make it a valuable component in the synthesis of new pharmaceutical compounds. Used in Pesticide Industry: In the pesticide industry, 2,3,5,6-Tetrafluoropyridine is used as an intermediate for creating effective and environmentally friendly pesticides. Its chemical properties contribute to the development of innovative formulations. Used in Rubber Industry: 2,3,5,6-Tetrafluoropyridine is utilized as an additive in the rubber industry to enhance the properties of rubber products, such as their durability and resistance to various environmental factors. Used in Dye Industry: This fluorine-containing pyridine intermediate is used in the dye industry to create new and vibrant colors for various applications, taking advantage of its unique chemical characteristics. Used in Special Reagents: 2,3,5,6-Tetrafluoropyridine is also employed as a special reagent in research and development, particularly in the synthesis of complex organic compounds and materials with specific properties.

What is the CAS number for 2,3,5,6-Tetrafluoropyridine?

The CAS number of 2,3,5,6-Tetrafluoropyridine is 2875-18-5.

What is 2,3,5,6-Tetrafluoropyridine (2875-18-5) used for?

Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medicine, pesticides, rubber, dyes and other fields. Since the 1960s, there have been hundreds of medicines, pesticides, dyes, and some special reagents developed with fluorine-containing aromatic compounds as intermediates. In the weakly basic pyridine ring, the nitrogen atom is more negatively charged, and then a fluorine atom with a strong electronegativity is introduced to synthesize a fluorine-containing pyridine intermediate.InChI:InChI=1/C5H8F2O2/c1-3-9-4(8)5(2,6)7/h3H2,1-2H3

What is the 2,3,5,6-Tetrafluoropyridine?

2,3,5,6-Tetrafluoropyridine is clear colorless liquid, while it's Molecular Formula is C5HF4N. clear colorless liquid Used in Pharmaceutical Industry: 2,3,5,6-Tetrafluoropyridine is used as an intermediate for the development of various medicines. Its strong electronegativity and unique chemical properties make it a valuable component in the synthesis of new pharmaceutical compounds. Used in Pesticide Industry: In the pesticide industry, 2,3,5,6-Tetrafluoropyridine is used as an intermediate for creating effective and environmentally friendly pesticides. Its chemical properties contribute to the development of innovative formulations. Used in Rubber Industry: 2,3,5,6-Tetrafluoropyridine is utilized as an additive in the rubber industry to enhance the properties of rubber products, such as their durability and resistance to various environmental factors. Used in Dye Industry: This fluorine-containing pyridine intermediate is used in the dye industry to create new and vibrant colors for various applications, taking advantage of its unique chemical characteristics. Used in Special Reagents: 2,3,5,6-Tetrafluoropyridine is also employed as a special reagent in research and development, particularly in the synthesis of complex organic compounds and materials with specific properties.

What is the CAS number for 2,3,5,6-Tetrafluoropyridine?

The CAS number of 2,3,5,6-Tetrafluoropyridine is 2875-18-5.

What is 2,3,5,6-Tetrafluoropyridine (2875-18-5) used for?

Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medicine, pesticides, rubber, dyes and other fields. Since the 1960s, there have been hundreds of medicines, pesticides, dyes, and some special reagents developed with fluorine-containing aromatic compounds as intermediates. In the weakly basic pyridine ring, the nitrogen atom is more negatively charged, and then a fluorine atom with a strong electronegativity is introduced to synthesize a fluorine-containing pyridine intermediate.InChI:InChI=1/C5H8F2O2/c1-3-9-4(8)5(2,6)7/h3H2,1-2H3

Product classification

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2875-18-5

Product Name：2,3,5,6-Tetrafluoropyridine
Molecular Formula：C₅HF₄N
Purity：99%
Molecular Weight：151.063

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Product Details;

CasNo： 2875-18-5

Molecular Formula： C₅HF₄N

Appearance： clear colorless liquid

Factory Sells Best Quality 2,3,5,6-Tetrafluoropyridine 2875-18-5 with steady supply

Molecular Formula:C5HF4N
Molecular Weight:151.063
Appearance/Colour:clear colorless liquid
Vapor Pressure:42.2mmHg at 25°C
Refractive Index:n20/D 1.4046(lit.)
Boiling Point:106 °C at 760 mmHg
PKA:-10.94±0.20(Predicted)
Flash Point:30.6 °C
PSA：12.89000
Density:1.518 g/cm³
LogP:1.63800

2,3,5,6-Tetrafluoropyridine(Cas 2875-18-5) Usage

Synthesis

Catalytic reduction of aryl chlorides, bromides and iodides is well documented, however, aryl fluorides do not readily react under these conditions, owing to the strong C-F bond and the high activation barrier to bond breaking. Work in our laboratories showed that at high temperatures, pentafluoropyridine was converted to 2,3,5,6- tetrafluoropyridine using a palladium catalyst.

Preparation

An autoclave sprayed with PTFE was charged with pentafluoropyridine (20.0 g, ?118 mmol), HBr (32.0 g, 400 mmol) and sulpholane (40 cm3) and heated at 200 ℃ for ?48 h. The mixture was added to water and extracted into ether. The ether solution was ?shown to contain pentafluoropyridine (79%) and 2,3,5,6-tetrafluoropyridine (21%) by ?comparison of their GCMS and fluorine nmr spectra with authentic samples.

InChI:InChI=1/C5H8F2O2/c1-3-9-4(8)5(2,6)7/h3H2,1-2H3

2875-18-5 Relevant articles

Mechanistic study of Ru-NHC-catalyzed hydrodefluorination of fluoropyridines: The influence of the NHC on the regioselectivity of C-F activation and chemoselectivity of C-F versus C-H bond cleavage

McKay, David,Riddlestone, Ian M.,Macgregor, Stuart A.,Mahon, Mary F.,Whittlesey, Michael K.

, p. 776 - 787 (2015)

We describe a combined experimental and ...

Dual C-F, C-H Functionalization via Photocatalysis: Access to Multifluorinated Biaryls

Senaweera, Sameera,Weaver, Jimmie D.

, p. 2520 - 2523 (2016)

Multifluorinated biaryls are challenging...

Dual Photoredox-/Palladium-Catalyzed Cross-Electrophile Couplings of Polyfluoroarenes with Aryl Halides and Triflates

Qin, Jian,Zhu, Shengqing,Chu, Lingling

supporting information, p. 2246 - 2252 (2021/04/02)

A visible-light photoredox-/Pd-catalyzed...

Photoredox/Nickel Dual-Catalyzed Reductive Cross Coupling of Aryl Halides Using an Organic Reducing Agent

Bülow, Raoul F.,Dewanji, Abhishek,Rueping, Magnus

supporting information, p. 1611 - 1617 (2020/03/13)

A successful protocol for the reductive ...

Dihydridoboranes: Selective Reagents for Hydroboration and Hydrodefluorination

Phillips, Nicholas A.,O'hanlon, James,Hooper, Thomas N.,White, Andrew J. P.,Crimmin, Mark R.

supporting information, p. 7289 - 7293 (2019/10/08)

The preparation of a new series of dihyd...

Hydrodefluorination of fluoroaromatics by isopropyl alcohol catalyzed by a ruthenium NHC complex. An unusual role of the carbene ligand

Mai, Van Hung,Nikonov, Georgii I.

, p. 7956 - 7961 (2018/05/23)

The NHC (NHC = N-heterocyclic carbene) c...

2875-18-5 Process route

: 700-16-3
Pentafluoropyridine

: 82878-63-5
3,4-difluoropyridine

: 67815-54-7
3,4,5-trifluoropyridine

: 3512-16-1
2,3,4,5-tetrafluoropyridine

: 2875-18-5
2,3,5,6-tetrafluoropyridine

: 76469-41-5
2,3,5‐trifluoropyridine

Conditions

Conditions	Yield
With triethylsilane; α,α,α-trifluorotoluene; C₆₄H₆₈N₂OP₂Ru; In tetrahydrofuran; at 69.84 ℃; for 28h; Time; stereoselective reaction; Schlenk technique; Glovebox;	42 %Spectr. 22 %Spectr. 21 %Spectr. 7 %Spectr. 3 %Spectr.
With triethylsilane; α,α,α-trifluorotoluene; C₆₄H₆₈N₂OP₂Ru; In tetrahydrofuran; at 89.84 ℃; for 28h; Time; Temperature; stereoselective reaction; Schlenk technique; Glovebox;	41 %Spectr. 26 %Spectr. 20 %Spectr. 8 %Spectr. 2 %Spectr.

: 16297-29-3
2,3,5,6-tetrafluoropyridin-4-yltrimethylsilan

: 2875-18-5
2,3,5,6-tetrafluoropyridine

: 700-16-3
Pentafluoropyridine

: 420-56-4
trimethylsilyl fluoride

: 3511-91-9
octafluoro dipyridyl-(4,4')