877674-77-6
- Product Name：(+)-(Z)-7-Chloro-2-(2,2-Dimethylcyclopropanecarbonylamino)-2-heptenoic Acid
- Molecular Formula：C13H20ClNO3
- Purity：99%
- Molecular Weight：273.76
Product Details;
CasNo： 877674-77-6
Molecular Formula： C13H20ClNO3
Reputable manufacturer supply (+)-(Z)-7-Chloro-2-(2,2-Dimethylcyclopropanecarbonylamino)-2-heptenoic Acid 877674-77-6 in stock with high standard
- Molecular Formula:C13H20ClNO3
- Molecular Weight:273.76
- Boiling Point:504.547 °C at 760 mmHg
- Flash Point:258.941 °C
- PSA：69.89000
- Density:1.189 g/cm3
- LogP:3.36660
877674-77-6 Relevant articles
Cilastatin sodium intermediate preparation method
-
Paragraph 0036-0037; 0042-0055, (2020/03/09)
The invention belongs to the technical f...
Refining method of cilastatin
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Paragraph 0036; 0041, (2018/01/19)
The invention provides a refining method...
Purification method of ethyl 7-chloro-2-oxoheptanoate
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Paragraph 0007; 0124, (2017/01/19)
The invention provides a purification me...
An improved process for the preparation of cilastatin acid
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Page/Page column 5, (2012/02/04)
The present invention relates to an impr...
877674-77-6 Process route
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C17H28ClNO3
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- 877674-77-6,166037-21-4
(Z)-7-chloro-2 ((2s)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid
Conditions
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; In water; at -6 - 75 ℃; for 15.5h;
|
77.26% |
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(Z)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid ethyl ester
- 877758-94-6
(Z)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid ethyl ester
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- 877674-77-6,166037-21-4
(Z)-7-chloro-2 ((2s)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid
Conditions
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; In water; at -10 - 70 ℃; for 9h; Reagent/catalyst; Temperature;
|
79.31% |
|
With ethanol; sodium hydroxide; at 45 - 50 ℃; for 10h; Reflux;
|
57.8% |
|
(Z)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid ethyl ester; With sodium hydroxide; water; In acetonitrile; at 20 ℃;
With hydrogenchloride; water; pH=3.5; Product distribution / selectivity;
|
|
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(Z)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid ethyl ester; With sodium hydroxide; ethanol; water; at 20 ℃;
With hydrogenchloride; water; pH=3.5; Product distribution / selectivity;
|
|
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With sodium hydroxide; In 1,4-dioxane; cyclohexane; at 20 ℃; for 12h;
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877674-77-6 Upstream products
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877758-94-6
(Z)-7-chloro-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid ethyl ester
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1022895-92-6
ethyl 7-chloro-2-{[(1S)-2,2-dimethylcyclopropyl]formamido}hept-2-enoate
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78834-75-0
ethyl-7-Chloro-2-oxoheptanoate
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75885-58-4
(S)-2,2-dimethylcyclopropanecarboxamide
877674-77-6 Downstream products
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82009-34-5
cilastatine
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