139122-19-3
- Product Name：4-(2'-Hydroxyethyl)-2-Indolinone
- Molecular Formula：C10H11NO2
- Purity：99%
- Molecular Weight：177.203
Product Details;
CasNo： 139122-19-3
Molecular Formula： C10H11NO2
Appearance： Yellow solid
Factory sells 4-(2'-Hydroxyethyl)-2-Indolinone 139122-19-3 with sufficient production capacity
- Molecular Formula:C10H11NO2
- Molecular Weight:177.203
- Appearance/Colour:Yellow solid
- Vapor Pressure:0mmHg at 25°C
- Melting Point:148-150 °C
- Refractive Index:1.6
- Boiling Point:390.019 °C at 760 mmHg
- PKA:14.08±0.20(Predicted)
- Flash Point:189.677 °C
- PSA：49.33000
- Density:1.253 g/cm3
- LogP:0.85400
1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one(Cas 139122-19-3) Usage
InChI:InChI=1/C10H11NO2/c12-5-4-7-2-1-3-9-8(7)6-10(13)11-9/h1-3,12H,4-6H2,(H,11,13)
139122-19-3 Relevant articles
A new scalable route to 4-(2-hydroxyethyl)-1,3-dihydro-2 H-indol-2-one: A key intermediate for ropinirole hydrochloride
Chen, Huansheng,Chen, Yu,Yuan, Li,Zou, Qing
, p. 714 - 717 (2013)
A new and efficient manufacturing techno...
A process for preparing 4 - (2 - hydroxyethyl) - 1, 3 - dihydro - 2H - indole -2 - one of the new method
-
, (2019/04/04)
The invention discloses a novel method f...
Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands
Zhou, Benhua,Hong, Kwon Ho,Ji, Min,Cai, Jin
, p. 1597 - 1609 (2018/07/31)
Two series of hybrid analogues were desi...
Method for preparing ropinirole hydrochloride
-
, (2018/09/12)
The invention belongs to the technical f...
Improved preparation method for ropinirole hydrochloride
-
Paragraph 0048; 0049; 0050, (2016/10/09)
The invention discloses an improved prep...
139122-19-3 Process route
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![4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one](/upload/2025/1/2dc6c32a-4e2d-4ce8-aeca-1492f5ad5161.png)
- 139122-17-1
4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one
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- 139122-19-3
4-(2'-hydroxyethyl)-1,3-dihydro-2H-indol-2-one
| Conditions | Yield |
|---|---|
|
4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one; With hydrazine; 5%-palladium/activated carbon; In methanol; water; for 1h; Heating / reflux;
With methanol; sodium hydroxide; water; for 0.5h; Heating / reflux;
|
84% |
|
4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one; With palladium 10% on activated carbon; hydrazine hydrate; In methanol; for 3h; Reflux;
With water; sodium hydroxide; In methanol; for 2h; Reflux;
|
71% |
|
With palladium 10% on activated carbon; hydrazine hydrate; In methanol; for 1h; Reflux;
|
71% |
|
Multi-step reaction with 2 steps
1: hydrazine hydrate, 10percent Pd-C / methanol; H2O / 0.5 h / Heating
2: aq. NaOH / methanol / 0.5 h / Heating
With sodium hydroxide; palladium on activated charcoal; hydrazine hydrate; In methanol; water;
|
|
|
Multi-step reaction with 2 steps
1: palladium on activated charcoal; hydrazine hydrate
2: sodium hydroxide; water / Large scale
With palladium on activated charcoal; water; hydrazine hydrate; sodium hydroxide;
|
|
|
Multi-step reaction with 2 steps
1: hydrazine hydrate; palladium 10% on activated carbon / methanol
2: sodium hydroxide; water / methanol / Reflux
With hydrazine hydrate; palladium 10% on activated carbon; water; sodium hydroxide; In methanol;
|
|
|
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon / water; ethyl acetate / 3 h / Reflux
2: sodium hydroxide; water / methanol / 4 h / Reflux
With palladium 10% on activated carbon; water; sodium hydroxide; In methanol; water; ethyl acetate;
|
-
- 139122-18-2
4-(2-benzoyloxyethyl)-1,3-dihydro-2H-indolin-2-one
-
- 139122-19-3
4-(2'-hydroxyethyl)-1,3-dihydro-2H-indol-2-one
| Conditions | Yield |
|---|---|
|
With water; sodium hydroxide; In methanol; for 4h; Reflux;
|
95% |
|
With sodium hydroxide; In methanol; for 0.5h; Yield given; Heating;
|
|
|
With water; sodium hydroxide; Large scale;
|
48 kg |
|
With water; sodium hydroxide; In methanol; Reflux;
|
139122-19-3 Upstream products
-
168476-61-7
4-(2-acetoxyethyl)-1,3-dihydro-2H-indolin-2-one
-
139122-18-2
4-(2-benzoyloxyethyl)-1,3-dihydro-2H-indolin-2-one
-
493-05-0
isochromane
-
22901-09-3
2-(2-bromoethyl)benzaldehyde
139122-19-3 Downstream products
-
139122-22-8
2-(2'-oxo-2,3-dihydro-4-indolyl)ethyl benzenesulphonate
-
139122-20-6
2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate
-
91374-21-9
Ropinirole
-
120427-93-2
4-ethylenyl-1,3-dihydro-2H-indol-2-one
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