139122-20-6
- Product Name：4-(2'-Hydroxyethyl) Oxindole P-Toluenesulfonate
- Molecular Formula：C17H17NO4S
- Purity：99%
- Molecular Weight：331.392
Product Details;
CasNo： 139122-20-6
Molecular Formula： C17H17NO4S
Factory supply 4-(2'-Hydroxyethyl) Oxindole P-Toluenesulfonate 139122-20-6 with sufficient production capacity
- Molecular Formula:C17H17NO4S
- Molecular Weight:331.392
- Boiling Point:561.181 °C at 760 mmHg
- PKA:14.02±0.20(Predicted)
- Flash Point:293.192 °C
- PSA：80.85000
- Density:1.312 g/cm3
- LogP:3.65640
139122-20-6 Relevant articles
Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands
Zhou, Benhua,Hong, Kwon Ho,Ji, Min,Cai, Jin
, p. 1597 - 1609 (2018/07/31)
Two series of hybrid analogues were desi...
Method for preparing ropinirole hydrochloride
-
Paragraph 0062; 0063; 0064, (2018/09/12)
The invention belongs to the technical f...
Indoline-2-ketone D3 receptor ligand and preparation method and application thereof
-
Paragraph 0068; 0069, (2016/10/08)
The invention discloses an indoline-2-ke...
Improved preparation method for ropinirole hydrochloride
-
Paragraph 0051; 0052, (2016/10/09)
The invention discloses an improved prep...
139122-20-6 Process route
-
- 22901-09-3
2-(2-bromoethyl)benzaldehyde
-
- 139122-20-6
2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate
Conditions
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 6 steps
1: 80 percent / MeONa / methanol / 1 h / 0 °C
2: 53 percent / AcCl, FeCl3 / CH2Cl2 / 3 h / 0 - 5 °C
3: 95 percent / aq. NaH2PO2 / 10percent Pd-C / ethyl acetate / 0.58 h / Heating
4: 89 percent / ethanol; H2O / 24 h / Heating
5: 70 percent / aq. HCl / 2.5 h / Heating
6: 87 percent / pyridine / CH2Cl2 / 4 h / 5 - 10 °C
With pyridine; hydrogenchloride; sodium hypophosphite; sodium methylate; iron(III) chloride; acetyl chloride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; ethyl acetate;
|
-
- 98-59-9
p-toluenesulfonyl chloride
-
- 139122-19-3
4-(2'-hydroxyethyl)-1,3-dihydro-2H-indol-2-one
-
- 139122-20-6
2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate
Conditions
| Conditions | Yield |
|---|---|
|
With pyridine; In dichloromethane; at 5 - 10 ℃; for 4h;
|
87% |
|
With pyridine; Large scale;
|
87% |
|
With pyridine; In dichloromethane; at 5 - 10 ℃; for 3h;
|
86% |
|
In pyridine; dichloromethane; at 5 - 10 ℃; for 3h;
|
86% |
|
With pyridine; In dichloromethane; at 5 - 10 ℃; for 2h;
|
86% |
|
With pyridine; In dichloromethane; at 5 - 10 ℃; for 4.5h;
|
80% |
|
With pyridine; In dichloromethane; at 5 - 10 ℃; for 4.5h;
|
80% |
|
With pyridine; In dichloromethane; at 0 - 20 ℃;
|
|
|
With pyridine; at 20 ℃; for 2h;
|
139122-20-6 Upstream products
-
98-59-9
p-toluenesulfonyl chloride
-
139122-19-3
4-(2'-hydroxyethyl)-1,3-dihydro-2H-indol-2-one
-
493-05-0
isochromane
-
22901-09-3
2-(2-bromoethyl)benzaldehyde
139122-20-6 Downstream products
-
91374-20-8
ropinirole hydrochloride
Relevant Products
-
-
N,N-Diethyl-2-Methyl-3-NitrophenylethylamineCAS：91374-23-1
-
Cyclohexane Carboxylic Acid ChlorideCAS：2719-27-9
